PRODUCT INFO
Denamarin chewable tablets for dogs of all sizes are a nutritional supplement for dogs intended to improve and support liver function.

WHAT THIS PRODUCT CURES
Denamarin's active ingredients, SAMe (S-adenosilmethionine) and silybin, enhance liver's antioxidative and regenerative properties, improve bile flow and aid digestion in dogs and cats. It has been recently proven that Denamarin also supports brain health in older animals.

PET SYMPTOMS
Liver is “the chemical factory” of the body; it has the main part in all processes of detoxification in the body and plays an important role in digestion (production of  bile), blood clotting and vitamin absorption. If liver function is somehow compromised, due to overload of toxins, the animal’s overall condition will be deteriorated and general health jeopardized. There are a large number of diseases and conditions that can stop liver from functioning properly. The symptoms of liver failure usually include vomiting, loss of appetite with weight loss, changes in stool appearance and weakness. In cases of advanced liver disease more specific signs can be seen, such as jaundice, swollen abdomen (caused by accumulation of fluid), confusion and seizures. Laboratory tests upon veterinary examination will show impaired liver function.

PET AILMENTS
Numerous diseases, chemicals, drugs and toxins can damage the liver. There are certain viral, parasitic and bacterial diseases that can directly damage the liver, such as leptospirosis, heartworm infection or infectious canine hepatitis. Metastatic tumors and certain metabolic diseases (Cushing’s syndrome, diabetes mellitus) can also lead to liver failure. Numerous drugs can damage the liver, usually as a result of prolonged use and excessive dosage. Certain chemicals can also lead to liver toxicity, such as iron, arsenic, lead, etc. Plants like ragwort, certain mushrooms and mold contaminating food can also cause liver damage.

RELATIVE INFO ON BREEDS MOST ASSOCIATED WITH THIS AILMENT
There are certain breeds of dogs and cats genetically predisposed to various liver issues. For example, Dobermans, Dalmatians, Samoyeds, Cairn Terriers are more prone to chronic hepatitis. Siamese, Burmese, Abyssinian, oriental shorthair and domestic shorthair cats are genetically predisposed to amyloidosis (protein deposition in liver).

QUESTIONS FOR MY VET

1. Are there any known side effects to Denamarin?
a) There are no known adverse reactions to Denamarin; all of its active ingredients have been proven to be very well tolerated by dogs and cats.

2. How can I know if Denamarin is working for my pet?
a) Be sure to monitor your changes in your pet’s attitude, activities and appetite. During the regular veterinary checkups your vet will perform the necessary tests to determine whether there has been any significant improvement in your pet’s condition since the beginning of Denamarin administration.

3. Is Denamarin safe to be used with other supplements for liver support?
a) Since there are no known interactions of Denamarin with other supplements or drugs, it is safe to combine it with other supplements, not only for liver support but other kinds as well.

4. Are there other liver support supplements for pets available on the market?
a) There are over the counter products available in drug stores or pet food stores that provide certain ingredients found in Denamarin. However, amounts of those useful ingredients are not standardized for dogs and cats and such liver support products may not provide sufficient source of these compounds for your pets.

5. How does Denamarin help my pet’s brain health?
a) SAMe, S-adenosilmethionine, is an important protective compound protecting the brain. Denamarin is a reliable source of SAMe for dogs and cats. It has been proven beneficial for brain health, especially in older patients.

6. Can Denamarin be administered with food?
a) It is best to administer Denamarin on an empty stomach, as the presence of food can affect the absorption of SAMe. But if your pet is reluctant to ingest the tablet, it can be given in a small bite of food.

HOW IT WORKS
Denamarin increases detoxifying properties of the liver. Its active ingredients, SAMe (S-adenosilmethionine) and silybin work in synergy to help optimize liver’s structural integrity and its numerous functions. S-adenosilmethionine helps in protecting liver cells from damage and destruction, at the same time improving their power or reparation and regeneration. Silybin stimulates the flow of bile through the liver and improves the digestion, as well as liver’s detoxifying properties.

DIRECTIONS FOR USE
It is best to administer the Denamarin chewable tablets on an empty stomach, at least one hour before feeding. The presence of food can decrease the absorption of SAMe. If the animal is reluctant to ingest the tablet, it can be given in small portion of food.

DOSAGE AND ADMINISTRATION
If the animal must receive more than one chewable tablet a day, the total number of daily tablets can be divided into two administrations during the day; morning and evening.

Denamarin tablets dosage instructions for dogs of all sizes:

INGREDIENTS
Denamarine chewable tablet for dogs of all sizes contains 225 mg of S-adenosilmethionine and 24 mg of silibyn A+B.

PRODUCT CAUTIONS

• This product is for veterinary use only and is available only from your veterinarian.
  
• Keep away from children.

STORAGE AND DISPOSAL

• Store in a cool, dry place.
  
• Keep the lid of the bottle tightly secured to ensure freshness.
  
• Tablets are sensitive to heat and moisture and should not be crumbled or split.
  

BRAND VS. GENERIC COMPARISON
Denamarin for All Dog Sizes is the only high quality liver supportive pet supplement on the market and the only one provides optimal levels of both SAMe and silybin for dogs and cats. There are certain over-the-counter products that provide the same active ingredients as Denamarin, but not in same concentrations. They are not as effective as Denamarin, may be somewhat cheaper and can appear in different packages.

Product Info

Adequan is an injectable drug for horses that is used to improve symptoms caused by arthritis. The box contains one 50ml vial, which is enough for 10 doses.

What the product cures

The medication helps to alleviate the symptoms brought on by both degenerative arthritis and arthritis caused by trauma. Veterinarians also often prescribe Adequan for equines that have had orthopedic surgery, in order to help with inflammation and aid in the recovery process.

Pet Symptoms

Equine arthritis is a progressive disease that causes permanent degeneration of the joint cartilage. In a healthy horse, the cartilage is sleek and allows the joints to move freely and absorb shock from moving as it normally should. With arthritis, the cartilage starts to deteriorate, making its surface vulnerable and leads to problems such as a stiff gait and general discomfort.

The symptoms caused by arthritis can come and go or be mild enough, that it’s difficult to detect it early on. As a result, the condition tends to be diagnosed several weeks or months after it has developed. However, there are common symptoms you can look out for that may indicate arthritis in your horse. Some of these symptoms include; lying down for longer periods, trouble rising from a lying position, decreased activity, abnormal behavior, moving slowly when in cold climate, stiff joints that improve with movement, lameness, joint inflammation, reduced appetite, and unusual wasting of the muscle. 

Unfortunately, there is no cure for equine arthritis, but it can be managed and the progression of the disease can be slowed down in most cases.

Pet Ailments

Approximately 60% of lameness cases in equines are caused by arthritis, which means there is a high risk of developing the condition.Although there is no known cause for arthritis, there are factors that are thought to contribute to its development. Some of these factors are; trauma/injury (due to inflammation being triggered), repetitive movement (causes wear and tear of the tissue and joint structures), and bacterial infections that may trigger inflammation.

Relative info on breed most associated with this ailment

Currently, there is no specific horse breed that is thought to be more susceptible to getting arthritis than another. Even though arthritis may be influenced by secondary conditions such as trauma, research has found that all horses are predisposed to the disease as they age. In 1999, a study was conducted and published in the Equine Vet Journal, which showed that wild mustang horses also suffered from arthritis symptoms. This means that even in their natural habitat, without being worked, exercised, etc. horses are prone to arthritis as they get older.

Questions for the vet & product

1.Should I inform my vet of anything before my horse starts Adequan?

Before starting your horse on Adequan Equine 100mg/1ml 50ml -  10 Dose, let your vet know if he/she is suffering from renal or liver disease, or has a condition affecting the body’s ability to form clots. The drug has not been tested for safety in use of pregnant, nursing, or breeding equines, so it is important that you tell your vet about these things as well. 

2. What should be done if a dose is missed?

If you forget to give your horse a dose, give it as soon as possible. However, if it is almost time for the next dose to be given, wait until then and continue with your regular schedule. Do NOT administer twice the dose to make up for the skipped one.

3. What if I overdose my horse on Adequan?

Overdosing a horse with Adequan is rare, but if you are concerned that this may be your situation, call or visit the closest veterinary emergency hospital for professional help.

4. Is there any medication that should be avoided while my horse is on Adequan?

There are currently no medications known to be contraindicated with the use of Adequan. However, always speak with your vet before giving any new drugs, supplements, or even vitamins to your horse.

5. Does Adequan cause any side effects?

Adequan side effects are uncommon, but may include diarrhea and unusual bleeding (from nose, stool, etc.). Seek immediate veterinary help if you believe your horse is experiencing any side effects or an allergic reaction (swollen face, shaking, vomiting, pale gums, collapse, and shock) from the medication.

How it Works

Certain enzymes in the joints cause the destruction of cartilage, leading to arthritis. Adequan stops these enzymes from causing damage, resulting in less inflammation and more synovial joint fluid to help improve movement.

Directions for use

Adequan can only be obtained with a prescription and should be administered exactly as directed by your vet.

Dosage and administration:  Adequan is an injectable solution, which should be given intramuscularly at a dosage of 500mg every four days for four weeks. The injection area should be cleaned and disinfected before administration takes place.

Ingredients

Every ml of Adequan has 100mg of Polysulfated Glycosaminoglycan, 0.9% v/v of Benzyl Alcohol, and water. Sodium Hydroxide and Hydrochloric Acid are ingredients that may also be included.

Product Cautions

The drug has not been tested for safety in use of pregnant, nursing, or breeding equines.

Before starting your horse on Adequan, let your vet know if he/she is suffering from renal or liver disease, or has a condition affecting the body’s ability to form clots.

Adequan should only be administered via the muscle. 

Do NOT use in equines with a sensitivity to Polysulfated Glycosaminoglycan or other ingredients listed on the bottle.

The medication should NOT be mixed with additional medication or chemicals.

Ask a veterinary professional for help if you are not sure about or uncomfortable with administering an I.M. injection to your horse.

Only give the medication to the horse it was prescribed for.

PHYSICAL OR CHEMICAL HAZARDS:

Store in a safe area where children and pets cannot reach. Adequan is NOT for use in humans.

FIRST AID:

If swallowed:  Contact the poison control center and speak with a doctor for professional guidance. While you’re waiting, water can be provided for the person only if he or she is conscious and can swallow. Otherwise, wait for further instructions from the poison control physician. Do not induce vomiting, unless instructed to do so by a doctor.

If in eyes:  May result in irritation. Use water to flush the eyes immediately for about 20 minutes. See a doctor if problems persist.

If on skin:  May result in irritation. Take off any clothing that has been soiled with the medication, and use soap/water to clean the affected area thoroughly.

Storage & Disposal

Storage:  Keep at room temperature between 20 and 25 degrees Celsius.

Disposal:  Do NOT mix with other substances. Contact a local waste agency on more information regarding proper disposal of medication or empty containers.