PRODUCT INFO
Denamarin chewable tablets for dogs of all sizes are a nutritional supplement for dogs intended to improve and support liver function.

WHAT THIS PRODUCT CURES
Denamarin's active ingredients, SAMe (S-adenosilmethionine) and silybin, enhance liver's antioxidative and regenerative properties, improve bile flow and aid digestion in dogs and cats. It has been recently proven that Denamarin also supports brain health in older animals.

PET SYMPTOMS
Liver is “the chemical factory” of the body; it has the main part in all processes of detoxification in the body and plays an important role in digestion (production of  bile), blood clotting and vitamin absorption. If liver function is somehow compromised, due to overload of toxins, the animal’s overall condition will be deteriorated and general health jeopardized. There are a large number of diseases and conditions that can stop liver from functioning properly. The symptoms of liver failure usually include vomiting, loss of appetite with weight loss, changes in stool appearance and weakness. In cases of advanced liver disease more specific signs can be seen, such as jaundice, swollen abdomen (caused by accumulation of fluid), confusion and seizures. Laboratory tests upon veterinary examination will show impaired liver function.

PET AILMENTS
Numerous diseases, chemicals, drugs and toxins can damage the liver. There are certain viral, parasitic and bacterial diseases that can directly damage the liver, such as leptospirosis, heartworm infection or infectious canine hepatitis. Metastatic tumors and certain metabolic diseases (Cushing’s syndrome, diabetes mellitus) can also lead to liver failure. Numerous drugs can damage the liver, usually as a result of prolonged use and excessive dosage. Certain chemicals can also lead to liver toxicity, such as iron, arsenic, lead, etc. Plants like ragwort, certain mushrooms and mold contaminating food can also cause liver damage.

RELATIVE INFO ON BREEDS MOST ASSOCIATED WITH THIS AILMENT
There are certain breeds of dogs and cats genetically predisposed to various liver issues. For example, Dobermans, Dalmatians, Samoyeds, Cairn Terriers are more prone to chronic hepatitis. Siamese, Burmese, Abyssinian, oriental shorthair and domestic shorthair cats are genetically predisposed to amyloidosis (protein deposition in liver).

QUESTIONS FOR MY VET

1. Are there any known side effects to Denamarin?
a) There are no known adverse reactions to Denamarin; all of its active ingredients have been proven to be very well tolerated by dogs and cats.

2. How can I know if Denamarin is working for my pet?
a) Be sure to monitor your changes in your pet’s attitude, activities and appetite. During the regular veterinary checkups your vet will perform the necessary tests to determine whether there has been any significant improvement in your pet’s condition since the beginning of Denamarin administration.

3. Is Denamarin safe to be used with other supplements for liver support?
a) Since there are no known interactions of Denamarin with other supplements or drugs, it is safe to combine it with other supplements, not only for liver support but other kinds as well.

4. Are there other liver support supplements for pets available on the market?
a) There are over the counter products available in drug stores or pet food stores that provide certain ingredients found in Denamarin. However, amounts of those useful ingredients are not standardized for dogs and cats and such liver support products may not provide sufficient source of these compounds for your pets.

5. How does Denamarin help my pet’s brain health?
a) SAMe, S-adenosilmethionine, is an important protective compound protecting the brain. Denamarin is a reliable source of SAMe for dogs and cats. It has been proven beneficial for brain health, especially in older patients.

6. Can Denamarin be administered with food?
a) It is best to administer Denamarin on an empty stomach, as the presence of food can affect the absorption of SAMe. But if your pet is reluctant to ingest the tablet, it can be given in a small bite of food.

HOW IT WORKS
Denamarin increases detoxifying properties of the liver. Its active ingredients, SAMe (S-adenosilmethionine) and silybin work in synergy to help optimize liver’s structural integrity and its numerous functions. S-adenosilmethionine helps in protecting liver cells from damage and destruction, at the same time improving their power or reparation and regeneration. Silybin stimulates the flow of bile through the liver and improves the digestion, as well as liver’s detoxifying properties.

DIRECTIONS FOR USE
It is best to administer the Denamarin chewable tablets on an empty stomach, at least one hour before feeding. The presence of food can decrease the absorption of SAMe. If the animal is reluctant to ingest the tablet, it can be given in small portion of food.

DOSAGE AND ADMINISTRATION
If the animal must receive more than one chewable tablet a day, the total number of daily tablets can be divided into two administrations during the day; morning and evening.

Denamarin tablets dosage instructions for dogs of all sizes:

INGREDIENTS
Denamarine chewable tablet for dogs of all sizes contains 225 mg of S-adenosilmethionine and 24 mg of silibyn A+B.

PRODUCT CAUTIONS

• This product is for veterinary use only and is available only from your veterinarian.
  
• Keep away from children.

STORAGE AND DISPOSAL

• Store in a cool, dry place.
  
• Keep the lid of the bottle tightly secured to ensure freshness.
  
• Tablets are sensitive to heat and moisture and should not be crumbled or split.
  

BRAND VS. GENERIC COMPARISON
Denamarin for All Dog Sizes is the only high quality liver supportive pet supplement on the market and the only one provides optimal levels of both SAMe and silybin for dogs and cats. There are certain over-the-counter products that provide the same active ingredients as Denamarin, but not in same concentrations. They are not as effective as Denamarin, may be somewhat cheaper and can appear in different packages.

PRODUCT INFO
Deramaxx chewable tablets are a non-steroidal anti-inflammatory drug for dogs only.

WHAT THIS PRODUCT CURES
Deramaxx controls pain and inflammation in dogs, especially after orthopedic and dental operative procedures as well as in osteoarthritis patients.

PET SYMPTOMS
As a result of hereditary predisposition, natural aging processes or injury, a significant number of dogs are suffering from osteoarthritis. It is the degenerative joint condition, most commonly affecting limb joints such as hips, elbows, ankles or knees. The first sign of this condition is usually the pain in the affected limb. Since the animals cannot tell us if they are in pain, we need to be able to recognize the changes in their behavior. Animals with painful joints will often show reluctance when required to climb stairs or jump on the couch, for example. In certain cases, they will have difficulties sitting, rising or squatting. They are not eager to exercise and often display stiffness after physical activity. In severe cases of pain, there will even be visible loss of appetite and weight loss. The animals are likely to spare the affected limb and can be lame if the pain and the arthritic changes have advanced. Upon detailed examination of the animal, it can be noticed that the affected joints are painful and inflamed (swollen, warm). 

PET AILMENTS
Osteoarthritis is the most common cause of joint pain in dogs. It is the degenerative disease of joints, caused by the injuries or as a result of genetic predisposition and old age. Osteoarthritis most commonly affects hips, knees and elbows.

RELATIVE INFO ON BREEDS MOST ASSOCIATED WITH THIS AILMENT
Osteoarthritis is usually the condition of older dogs and can be a part of the aging process. However, large and overweight dogs are more likely to develop joint deformations. Dog breeds with high hereditary predisposition for osteoarthritis are Rottweilers, Great Danes, Mastiffs, Golden Retrievers, Newfoundlands, Labrador Retrievers, German Shepherds, Dobermans and St. Bernards.

QUESTIONS FOR MY VET

1. What is Deramaxx and how it works?
Deramaxx is a prescription non-steroidal anti-inflammatory drug (NSAID) in the form of tablets for control of pain and inflammation in dogs with osteoarthritis and after orthopedic surgical procedures.   

2. How can Deramaxx help my dog with osteoarthritis?
Osteoarthritis is a progressive and painful condition. Deramaxx cannot cure osteoarthritis, but it can control and decrease the accompanying pain and that way improve your dog’s quality of life. Of course, every animal is different and responds to the treatment differently. It is important to seek veterinary advice and make a detailed plan for condition management.

3. In what cases should my dog not be given Deramaxx?
If your dog has a history of known hypersensitivity to deracoxib (the active ingredient of Deramaxx), Aspirin or other NSAIDs or corticosteroids. Do not administer Deramaxx if your dog is suffering from bloody stool, decreased appetite, pre-existing kidney or liver diseases or has any condition that can lead to dehydration.

4. Does Deramaxx interact with other drugs?
Deramaxx should not be given with other NSAIDs or corticosteroids. Consult your veterinarian before administering Deramaxx. Mention all the drugs or dietary supplements your dog is currently taking.

5. What side effects can my dog have during Deramaxx treatment?
Although Deramaxx can cause certain side effects in dogs they are usually mild and rare. Side effects to Deramaxx include vomiting, diarrhea, change in stool color, changes in drinking and urination rhythm, decrease of appetite, depression, restlessness. If you notice any of the above mentioned side effects in your pet, stop administering Deramaxx and contact your veterinarian.

6. What should I do in case of overdose with Deramaxx tablets?
In case of accidental overdose, immediately seek veterinary assistance.

7. How can Deramaxx help my dog after orthopedic surgery?
Deramaxx can help control your dog’s pain and inflammation after orthopedic procedures if given according to the veterinary instructions and according to the instructions on the label.

8. What should I discuss with the vet before administering Deramaxx?
Talk to your veterinarian about any health issues your dog might be experiencing, such as digestive problems, kidney diseases, allergies. Be sure to mention all the drugs and/or dietary supplements your dog is currently taking or you plan to administer in the future. Inform your vet if your dog is currently pregnant or nursing.

HOW IT WORKS
Deramaxx is deracoxib, a non-steroid, anti-inflammatory drug of the coxib class. Deracoxib inhibits the Cyclooxygenase 1 and 2 (COX-1 and COX-2), enzymes responsible for production of inflammatory mediators, prostaglandins. Inflammatory mediators are responsible for the development of pain and inflammation symptoms. That way deracoxib directly stops those symptoms from appearing.

DIRECTIONS FOR USE
Licensed veterinarian prescribes this medication. The instructions provided in the label should be strictly followed. Consider all the potential risks and benefits of Deramaxx before deciding to administer Deramaxx tablets to your pet. Deramaxx can be given with or without food, but be sure that your pet always has plenty of fresh water to drink. If you do not understand the instruction of the label or have any further questions concerning Deramaxx, contact your veterinarian or pharmacist.

DOSAGE AND ADMINISTRATION

• Deramaxx chewable tablets appear in five strengths: 12 mg, 25 mg, 50 mg, 75 mg and 100 mg. 
  
• The usual dose in the treatment of osteoarthritis pain and inflammation for dogs is 0.45-0.91 mg/lb per day (1-2 mg/kg per day) given when needed once a day.
  
• The usual dose in the treatment of postoperative orthopedic pain and inflammation for dogs is 1.4-1.8 mg/lb per day (3-5 mg/kg per day) given when needed once a day, but not longer than 7 days in a row. 
  
• The usual dose in the treatment of postoperative dental pain and inflammation for dogs is 0.45-0.91 mg/lb (1-2 mg/kg per day) given when needed once a day for 3 days. The first dose should be given 1 hour prior to the procedure, and the following doses should be for two more days.
  
• Small dogs that need less than 12.5 mg of Deramaxx can be accurately dosed through the use of 12 mg tablet, which can be split in half. Dosing of small dogs with bigger tablets can lead to inaccurate dosing and cause adverse reactions. 
  

INGREDIENTS
Deramaxx chewable tablets contain 12 mg, 25 mg, 50 mg, 75 mg or 100 mg of active ingredient deracoxib.

PRODUCT CAUTIONS

• For animal use only; not for use on humans. 
  
• Keep away from children. Consult a doctor in case of accidental human ingestion.
  
• This product is for dog use only, not to be used in cats. 
  

Follow the instructions provided in the drug label, especially on the issue of drug dosing, to avoid possible adverse reactions.
Prior to initiation of the Deramaxx treatment, dogs should undergo detailed veterinary checkup with appropriate laboratory tests.
The use of Deramaxx with other NSAIDs should be avoided to prevent the potential gastrointestinal ulceration or perforation. The safe use of Deramaxx in dogs younger than 4 months, pregnant or lactating bitches and dogs used for breeding has not been determined.
Dogs with history of hypersensitivity to Deramaxx or other NSAIDs should not use Deramaxx.

STORAGE AND DISPOSAL
Store Deramaxx tablets at the room temperature between 15 and 30°C.

BRAND VS GENERIC COMPARISON
There are no generic varieties of deracoxib available on the market. There are several possible substitutions containing different active ingredients and coming in different formulations.

PRODUCT INFO
Virbantel, manufactured by Virbrac inc., is an anthelmintic combination medication to treat internal parasites in dogs.

WHAT THIS PRODUCT CURES
Hookworms (Ancylostoma caninum, Ancylostoma braziliense, Roundworms (Toxocara canis, Toxascaris leonina), and Uncinaria stenocephala), and Tapeworms (Dipylidium caninum, Taenia pisiformis).

PET AILMENTS
Internal parasites cause aliments in dogs including; vomiting, dry textured hair, loss of weight, blood in the stool, diarrhea, and an overall poor condition.

RELATIVE INFO ON BREED MOST ASSOCIATED WITH THIS AILMENT
Internal parasites affect dogs of all species, gender, age, and size. The most common internal parasites are; Hookworms (Ancylostoma caninum, Roundworms (Toxocara canis, Toxascaris leonina), Ancylostoma braziliense, and Uncinaria stenocephala), and Tapeworms (Dipylidium caninum, Taenia pisiformis).

QUESTIONS FOR MY VET

1.What steps should I take if my pet has adverse effects from product?
Discontinue use and contact your veterinarian immediately.

2. What side effects could my pet develop while taking this medication?
Vomiting, loose stools, and perhaps blood within the stools.

3. Will this product alone terminate the internal parasite problem in my pet?
Yes and no. This product will terminate the present worms your pet has but will not prevent recontamination. Keep in mind fleas and mosquitoes are carriers of some parasites. A flea and mosquito treatment must also be used.

4. Do I need to isolate my pet while treatment takes place?
It is recommended to isolate pets from other pets during treatment to prevent contamination to others.

5. If isolation during treatment is recommended, are there other steps in protocol I should be aware of?
Yes. Do not allow infected pets to share litter boxes or come in contact with infected feces. Remove all fecal matter from yard area to prevent contamination to other pets or re-contamination to your pet. 

6. I have been treating my pet for hookworms and noted a rash on my arm. Could this be an infection?
Yes. This hookworm can penetrate the human skin causing a condition called cutaneous larval migrants, more commonly called creeping eruption or ground itch in lament terms. These hookworms can do one of two things; one, they can either simply cause a severe rash while they burrow under the skin or two, migrate into the human intestine and cause a condition known as eosinophilic enteritis.

7. How can I prevent my pet’s hookworms from contaminating me?
Always wear protective foot and hand gear. The shoes you wear while entering the kennel of your dog should be washed daily and never worn anywhere else. Keep waste material in a sealed garbage container away from the home.

8. Can I become infected with tapeworms or roundworms?
To become infected with tapeworms or roundworms a person would have to ingest them. The change you would become infected is very slim.

How it Works: Virbantel is a combination medicine containing both pyrantel pamoate (30 mg) and praziquantel (30 mg) Pyrantel Pamoate interferes with the parasite’s transmition of nerves leading to paralysis and termination of hookworms.

DIRECTIONS FOR USE:
Dogs:

• Product is to be given orally and meant to be chewed.
  
• Medication can be given alongside food. 
  
• Break down large pills to ease digestion in small dogs. 
  
• Administer pills once a month. 

Pet owners; prevent overdose to your pet by scheduling the date to administer. Place a reminder or check off list to ensure dosage on appropriate day.

DOSAGE AND ADMINISTRATION:
Administer once monthly for prevention of hookworms, roundworms, and whipworms. Product is to be given according to weight. Pills are available for small, medium, and large dogs.

Ingredients
Active Ingredients (in each chewable):
Pyrantel pamoate (30 mg) and praziquantel (30 mg)

Product Cautions
Do not use this product in cats.
Not intended for use in puppies under 6 weeks of age.
Virbantel Chewable Tablets is Safe for all herding dog breeds, pregnant, and lactating females.
Pets: For use in Small Dogs and Puppies Only (6.0 to 25 pounds).

PHYSICAL OR CHEMICAL HAZARDS:

FIRST AID

If Swallowed: Immediately contact a poison control center and seek advice. If the affected person is in a state to swallow, offer them to sip a glass of water. Unless suggested by the doctor at poison control centre, do not encourage the person to vomit. If the affected becomes unconscious, do not administer anything though their mouth.

Storage: Store away from sunlight and moisture. Store it at room temperature.

Disposal: Empty containers should not be reused. Consign it to trash or look to the possibility of its recycling. Unused or leftover of the container should never be disposed in any drain. Seek help of local solid waste agency or call up 1-800-CLEANUP for instructions concerning disposal.

BRAND VS GENERIC COMPARISON: Virbantel chewable tablets for dog are the generic formation of heartgard plus. Both generic and name brand products contain pyrantel pamoate and praziquantel. 

Product Info

Adequan is an injectable drug for horses that is used to improve symptoms caused by arthritis. The box contains one 50ml vial, which is enough for 10 doses.

What the product cures

The medication helps to alleviate the symptoms brought on by both degenerative arthritis and arthritis caused by trauma. Veterinarians also often prescribe Adequan for equines that have had orthopedic surgery, in order to help with inflammation and aid in the recovery process.

Pet Symptoms

Equine arthritis is a progressive disease that causes permanent degeneration of the joint cartilage. In a healthy horse, the cartilage is sleek and allows the joints to move freely and absorb shock from moving as it normally should. With arthritis, the cartilage starts to deteriorate, making its surface vulnerable and leads to problems such as a stiff gait and general discomfort.

The symptoms caused by arthritis can come and go or be mild enough, that it’s difficult to detect it early on. As a result, the condition tends to be diagnosed several weeks or months after it has developed. However, there are common symptoms you can look out for that may indicate arthritis in your horse. Some of these symptoms include; lying down for longer periods, trouble rising from a lying position, decreased activity, abnormal behavior, moving slowly when in cold climate, stiff joints that improve with movement, lameness, joint inflammation, reduced appetite, and unusual wasting of the muscle. 

Unfortunately, there is no cure for equine arthritis, but it can be managed and the progression of the disease can be slowed down in most cases.

Pet Ailments

Approximately 60% of lameness cases in equines are caused by arthritis, which means there is a high risk of developing the condition.Although there is no known cause for arthritis, there are factors that are thought to contribute to its development. Some of these factors are; trauma/injury (due to inflammation being triggered), repetitive movement (causes wear and tear of the tissue and joint structures), and bacterial infections that may trigger inflammation.

Relative info on breed most associated with this ailment

Currently, there is no specific horse breed that is thought to be more susceptible to getting arthritis than another. Even though arthritis may be influenced by secondary conditions such as trauma, research has found that all horses are predisposed to the disease as they age. In 1999, a study was conducted and published in the Equine Vet Journal, which showed that wild mustang horses also suffered from arthritis symptoms. This means that even in their natural habitat, without being worked, exercised, etc. horses are prone to arthritis as they get older.

Questions for the vet & product

1.Should I inform my vet of anything before my horse starts Adequan?

Before starting your horse on Adequan Equine 100mg/1ml 50ml -  10 Dose, let your vet know if he/she is suffering from renal or liver disease, or has a condition affecting the body’s ability to form clots. The drug has not been tested for safety in use of pregnant, nursing, or breeding equines, so it is important that you tell your vet about these things as well. 

2. What should be done if a dose is missed?

If you forget to give your horse a dose, give it as soon as possible. However, if it is almost time for the next dose to be given, wait until then and continue with your regular schedule. Do NOT administer twice the dose to make up for the skipped one.

3. What if I overdose my horse on Adequan?

Overdosing a horse with Adequan is rare, but if you are concerned that this may be your situation, call or visit the closest veterinary emergency hospital for professional help.

4. Is there any medication that should be avoided while my horse is on Adequan?

There are currently no medications known to be contraindicated with the use of Adequan. However, always speak with your vet before giving any new drugs, supplements, or even vitamins to your horse.

5. Does Adequan cause any side effects?

Adequan side effects are uncommon, but may include diarrhea and unusual bleeding (from nose, stool, etc.). Seek immediate veterinary help if you believe your horse is experiencing any side effects or an allergic reaction (swollen face, shaking, vomiting, pale gums, collapse, and shock) from the medication.

How it Works

Certain enzymes in the joints cause the destruction of cartilage, leading to arthritis. Adequan stops these enzymes from causing damage, resulting in less inflammation and more synovial joint fluid to help improve movement.

Directions for use

Adequan can only be obtained with a prescription and should be administered exactly as directed by your vet.

Dosage and administration:  Adequan is an injectable solution, which should be given intramuscularly at a dosage of 500mg every four days for four weeks. The injection area should be cleaned and disinfected before administration takes place.

Ingredients

Every ml of Adequan has 100mg of Polysulfated Glycosaminoglycan, 0.9% v/v of Benzyl Alcohol, and water. Sodium Hydroxide and Hydrochloric Acid are ingredients that may also be included.

Product Cautions

The drug has not been tested for safety in use of pregnant, nursing, or breeding equines.

Before starting your horse on Adequan, let your vet know if he/she is suffering from renal or liver disease, or has a condition affecting the body’s ability to form clots.

Adequan should only be administered via the muscle. 

Do NOT use in equines with a sensitivity to Polysulfated Glycosaminoglycan or other ingredients listed on the bottle.

The medication should NOT be mixed with additional medication or chemicals.

Ask a veterinary professional for help if you are not sure about or uncomfortable with administering an I.M. injection to your horse.

Only give the medication to the horse it was prescribed for.

PHYSICAL OR CHEMICAL HAZARDS:

Store in a safe area where children and pets cannot reach. Adequan is NOT for use in humans.

FIRST AID:

If swallowed:  Contact the poison control center and speak with a doctor for professional guidance. While you’re waiting, water can be provided for the person only if he or she is conscious and can swallow. Otherwise, wait for further instructions from the poison control physician. Do not induce vomiting, unless instructed to do so by a doctor.

If in eyes:  May result in irritation. Use water to flush the eyes immediately for about 20 minutes. See a doctor if problems persist.

If on skin:  May result in irritation. Take off any clothing that has been soiled with the medication, and use soap/water to clean the affected area thoroughly.

Storage & Disposal

Storage:  Keep at room temperature between 20 and 25 degrees Celsius.

Disposal:  Do NOT mix with other substances. Contact a local waste agency on more information regarding proper disposal of medication or empty containers.