PRODUCT INFO
Denamarin chewable tablets for dogs of all sizes are a nutritional supplement for dogs intended to improve and support liver function.

WHAT THIS PRODUCT CURES
Denamarin's active ingredients, SAMe (S-adenosilmethionine) and silybin, enhance liver's antioxidative and regenerative properties, improve bile flow and aid digestion in dogs and cats. It has been recently proven that Denamarin also supports brain health in older animals.

PET SYMPTOMS
Liver is “the chemical factory” of the body; it has the main part in all processes of detoxification in the body and plays an important role in digestion (production of  bile), blood clotting and vitamin absorption. If liver function is somehow compromised, due to overload of toxins, the animal’s overall condition will be deteriorated and general health jeopardized. There are a large number of diseases and conditions that can stop liver from functioning properly. The symptoms of liver failure usually include vomiting, loss of appetite with weight loss, changes in stool appearance and weakness. In cases of advanced liver disease more specific signs can be seen, such as jaundice, swollen abdomen (caused by accumulation of fluid), confusion and seizures. Laboratory tests upon veterinary examination will show impaired liver function.

PET AILMENTS
Numerous diseases, chemicals, drugs and toxins can damage the liver. There are certain viral, parasitic and bacterial diseases that can directly damage the liver, such as leptospirosis, heartworm infection or infectious canine hepatitis. Metastatic tumors and certain metabolic diseases (Cushing’s syndrome, diabetes mellitus) can also lead to liver failure. Numerous drugs can damage the liver, usually as a result of prolonged use and excessive dosage. Certain chemicals can also lead to liver toxicity, such as iron, arsenic, lead, etc. Plants like ragwort, certain mushrooms and mold contaminating food can also cause liver damage.

RELATIVE INFO ON BREEDS MOST ASSOCIATED WITH THIS AILMENT
There are certain breeds of dogs and cats genetically predisposed to various liver issues. For example, Dobermans, Dalmatians, Samoyeds, Cairn Terriers are more prone to chronic hepatitis. Siamese, Burmese, Abyssinian, oriental shorthair and domestic shorthair cats are genetically predisposed to amyloidosis (protein deposition in liver).

QUESTIONS FOR MY VET

1. Are there any known side effects to Denamarin?
a) There are no known adverse reactions to Denamarin; all of its active ingredients have been proven to be very well tolerated by dogs and cats.

2. How can I know if Denamarin is working for my pet?
a) Be sure to monitor your changes in your pet’s attitude, activities and appetite. During the regular veterinary checkups your vet will perform the necessary tests to determine whether there has been any significant improvement in your pet’s condition since the beginning of Denamarin administration.

3. Is Denamarin safe to be used with other supplements for liver support?
a) Since there are no known interactions of Denamarin with other supplements or drugs, it is safe to combine it with other supplements, not only for liver support but other kinds as well.

4. Are there other liver support supplements for pets available on the market?
a) There are over the counter products available in drug stores or pet food stores that provide certain ingredients found in Denamarin. However, amounts of those useful ingredients are not standardized for dogs and cats and such liver support products may not provide sufficient source of these compounds for your pets.

5. How does Denamarin help my pet’s brain health?
a) SAMe, S-adenosilmethionine, is an important protective compound protecting the brain. Denamarin is a reliable source of SAMe for dogs and cats. It has been proven beneficial for brain health, especially in older patients.

6. Can Denamarin be administered with food?
a) It is best to administer Denamarin on an empty stomach, as the presence of food can affect the absorption of SAMe. But if your pet is reluctant to ingest the tablet, it can be given in a small bite of food.

HOW IT WORKS
Denamarin increases detoxifying properties of the liver. Its active ingredients, SAMe (S-adenosilmethionine) and silybin work in synergy to help optimize liver’s structural integrity and its numerous functions. S-adenosilmethionine helps in protecting liver cells from damage and destruction, at the same time improving their power or reparation and regeneration. Silybin stimulates the flow of bile through the liver and improves the digestion, as well as liver’s detoxifying properties.

DIRECTIONS FOR USE
It is best to administer the Denamarin chewable tablets on an empty stomach, at least one hour before feeding. The presence of food can decrease the absorption of SAMe. If the animal is reluctant to ingest the tablet, it can be given in small portion of food.

DOSAGE AND ADMINISTRATION
If the animal must receive more than one chewable tablet a day, the total number of daily tablets can be divided into two administrations during the day; morning and evening.

Denamarin tablets dosage instructions for dogs of all sizes:

INGREDIENTS
Denamarine chewable tablet for dogs of all sizes contains 225 mg of S-adenosilmethionine and 24 mg of silibyn A+B.

PRODUCT CAUTIONS

• This product is for veterinary use only and is available only from your veterinarian.
  
• Keep away from children.

STORAGE AND DISPOSAL

• Store in a cool, dry place.
  
• Keep the lid of the bottle tightly secured to ensure freshness.
  
• Tablets are sensitive to heat and moisture and should not be crumbled or split.
  

BRAND VS. GENERIC COMPARISON
Denamarin for All Dog Sizes is the only high quality liver supportive pet supplement on the market and the only one provides optimal levels of both SAMe and silybin for dogs and cats. There are certain over-the-counter products that provide the same active ingredients as Denamarin, but not in same concentrations. They are not as effective as Denamarin, may be somewhat cheaper and can appear in different packages.

PRODUCT INFO
Deramaxx chewable tablets are a non-steroidal anti-inflammatory drug for dogs only.

WHAT THIS PRODUCT CURES
Deramaxx controls pain and inflammation in dogs, especially after orthopedic and dental operative procedures as well as in osteoarthritis patients.

PET SYMPTOMS
As a result of hereditary predisposition, natural aging processes or injury, a significant number of dogs are suffering from osteoarthritis. It is the degenerative joint condition, most commonly affecting limb joints such as hips, elbows, ankles or knees. The first sign of this condition is usually the pain in the affected limb. Since the animals cannot tell us if they are in pain, we need to be able to recognize the changes in their behavior. Animals with painful joints will often show reluctance when required to climb stairs or jump on the couch, for example. In certain cases, they will have difficulties sitting, rising or squatting. They are not eager to exercise and often display stiffness after physical activity. In severe cases of pain, there will even be visible loss of appetite and weight loss. The animals are likely to spare the affected limb and can be lame if the pain and the arthritic changes have advanced. Upon detailed examination of the animal, it can be noticed that the affected joints are painful and inflamed (swollen, warm). 

PET AILMENTS
Osteoarthritis is the most common cause of joint pain in dogs. It is the degenerative disease of joints, caused by the injuries or as a result of genetic predisposition and old age. Osteoarthritis most commonly affects hips, knees and elbows.

RELATIVE INFO ON BREEDS MOST ASSOCIATED WITH THIS AILMENT
Osteoarthritis is usually the condition of older dogs and can be a part of the aging process. However, large and overweight dogs are more likely to develop joint deformations. Dog breeds with high hereditary predisposition for osteoarthritis are Rottweilers, Great Danes, Mastiffs, Golden Retrievers, Newfoundlands, Labrador Retrievers, German Shepherds, Dobermans and St. Bernards.

QUESTIONS FOR MY VET

1. What is Deramaxx and how it works?
Deramaxx is a prescription non-steroidal anti-inflammatory drug (NSAID) in the form of tablets for control of pain and inflammation in dogs with osteoarthritis and after orthopedic surgical procedures.   

2. How can Deramaxx help my dog with osteoarthritis?
Osteoarthritis is a progressive and painful condition. Deramaxx cannot cure osteoarthritis, but it can control and decrease the accompanying pain and that way improve your dog’s quality of life. Of course, every animal is different and responds to the treatment differently. It is important to seek veterinary advice and make a detailed plan for condition management.

3. In what cases should my dog not be given Deramaxx?
If your dog has a history of known hypersensitivity to deracoxib (the active ingredient of Deramaxx), Aspirin or other NSAIDs or corticosteroids. Do not administer Deramaxx if your dog is suffering from bloody stool, decreased appetite, pre-existing kidney or liver diseases or has any condition that can lead to dehydration.

4. Does Deramaxx interact with other drugs?
Deramaxx should not be given with other NSAIDs or corticosteroids. Consult your veterinarian before administering Deramaxx. Mention all the drugs or dietary supplements your dog is currently taking.

5. What side effects can my dog have during Deramaxx treatment?
Although Deramaxx can cause certain side effects in dogs they are usually mild and rare. Side effects to Deramaxx include vomiting, diarrhea, change in stool color, changes in drinking and urination rhythm, decrease of appetite, depression, restlessness. If you notice any of the above mentioned side effects in your pet, stop administering Deramaxx and contact your veterinarian.

6. What should I do in case of overdose with Deramaxx tablets?
In case of accidental overdose, immediately seek veterinary assistance.

7. How can Deramaxx help my dog after orthopedic surgery?
Deramaxx can help control your dog’s pain and inflammation after orthopedic procedures if given according to the veterinary instructions and according to the instructions on the label.

8. What should I discuss with the vet before administering Deramaxx?
Talk to your veterinarian about any health issues your dog might be experiencing, such as digestive problems, kidney diseases, allergies. Be sure to mention all the drugs and/or dietary supplements your dog is currently taking or you plan to administer in the future. Inform your vet if your dog is currently pregnant or nursing.

HOW IT WORKS
Deramaxx is deracoxib, a non-steroid, anti-inflammatory drug of the coxib class. Deracoxib inhibits the Cyclooxygenase 1 and 2 (COX-1 and COX-2), enzymes responsible for production of inflammatory mediators, prostaglandins. Inflammatory mediators are responsible for the development of pain and inflammation symptoms. That way deracoxib directly stops those symptoms from appearing.

DIRECTIONS FOR USE
Licensed veterinarian prescribes this medication. The instructions provided in the label should be strictly followed. Consider all the potential risks and benefits of Deramaxx before deciding to administer Deramaxx tablets to your pet. Deramaxx can be given with or without food, but be sure that your pet always has plenty of fresh water to drink. If you do not understand the instruction of the label or have any further questions concerning Deramaxx, contact your veterinarian or pharmacist.

DOSAGE AND ADMINISTRATION

• Deramaxx chewable tablets appear in five strengths: 12 mg, 25 mg, 50 mg, 75 mg and 100 mg. 
  
• The usual dose in the treatment of osteoarthritis pain and inflammation for dogs is 0.45-0.91 mg/lb per day (1-2 mg/kg per day) given when needed once a day.
  
• The usual dose in the treatment of postoperative orthopedic pain and inflammation for dogs is 1.4-1.8 mg/lb per day (3-5 mg/kg per day) given when needed once a day, but not longer than 7 days in a row. 
  
• The usual dose in the treatment of postoperative dental pain and inflammation for dogs is 0.45-0.91 mg/lb (1-2 mg/kg per day) given when needed once a day for 3 days. The first dose should be given 1 hour prior to the procedure, and the following doses should be for two more days.
  
• Small dogs that need less than 12.5 mg of Deramaxx can be accurately dosed through the use of 12 mg tablet, which can be split in half. Dosing of small dogs with bigger tablets can lead to inaccurate dosing and cause adverse reactions. 
  

INGREDIENTS
Deramaxx chewable tablets contain 12 mg, 25 mg, 50 mg, 75 mg or 100 mg of active ingredient deracoxib.

PRODUCT CAUTIONS

• For animal use only; not for use on humans. 
  
• Keep away from children. Consult a doctor in case of accidental human ingestion.
  
• This product is for dog use only, not to be used in cats. 
  

Follow the instructions provided in the drug label, especially on the issue of drug dosing, to avoid possible adverse reactions.
Prior to initiation of the Deramaxx treatment, dogs should undergo detailed veterinary checkup with appropriate laboratory tests.
The use of Deramaxx with other NSAIDs should be avoided to prevent the potential gastrointestinal ulceration or perforation. The safe use of Deramaxx in dogs younger than 4 months, pregnant or lactating bitches and dogs used for breeding has not been determined.
Dogs with history of hypersensitivity to Deramaxx or other NSAIDs should not use Deramaxx.

STORAGE AND DISPOSAL
Store Deramaxx tablets at the room temperature between 15 and 30°C.

BRAND VS GENERIC COMPARISON
There are no generic varieties of deracoxib available on the market. There are several possible substitutions containing different active ingredients and coming in different formulations.